• br AhR Modulators It is now well

  2024-02-02

  

  AhR Modulators It is now well recognized that ligand-activated AhR induces an immune tolerance response by acting directly on the antigen-presenting DCs and indirectly by increasing the population of immunosuppressive Tregs 24, 95, 96. In addition to inhibiting the formation or depleting the AhR

• br Rapid nongenomic effects of corticosterone in

  2024-02-02

  

  Rapid nongenomic effects of corticosterone in an amphibian model Studies in the model organism, the roughskin newt, Taricha granulosa, over 30 years ago led to the discovery that stress can rapidly (within minutes) suppress sexual behavior (amplectic clasping) of male T. granulosa, an effect that

• Our in vitro data show

  2024-02-02

  

  Our in vitro data show that CyaA does not play a critical role in the bacterial adherence to mammalian cells. This observation is in contrast to previous studies that reported a role for CyaA in FHA-mediated adherence of B. pertussis bacteria to the respiratory epithelial mek inhibitor [37,38]. Thi

• Previous studies suggest that TGF contributes to the

  2024-02-02

  

  Previous studies suggest that TGF-β contributes to the pathogenesis of diabetic renal injury [47]. TGF-β stimulates matrix production and prevents matrix degradation, which leads to increase collagen deposition and glomerulosclerosis [48]. In the current study ABT702 significantly reduced renal coll

• Although effects of low concentrations of agonist were

  2024-02-02

  

  Although effects of low concentrations of agonist were not as thoroughly documented for heteromeric receptors such as the major VO-Ohpic trihydrate α4β2 nAChR, a similar mechanism of action was described to explain the potentiation of these receptors with low concentrations of acetylcholine-esteras

• In fact serotonin is a major modulator

  2024-02-02

  

  In fact, serotonin is a major modulator of dopaminergic (DA) neuronal activity through the 5-HT2C receptor. Studies have shown that the selective 5-HT2C receptor agonist Ro60-0175 blocks the burst-firing of mesolimbic DA neurons, which project from the ventral tegmental area (VTA) to the nucleus acc

• Caspase-6, human recombinant protein ATX LPA signaling in ca

  2024-02-02

  

  ATX/LPA signaling in cancer is also well known to promote chemotherapy and radiotherapy resistance [7]. Furthermore, others have recently shown that endothelial-derived ATX activity in renal cell carcinoma promotes renal tumorgenesis and acquired resistance to sunitinib through an IL-8-mediated mech

• Zhang et al screened three thousand compounds library and fo

  2024-02-02

  

  Zhang et al. screened three thousand compounds library and found two active 3,5,6-substituted indolin-2-one molecules. Further, they designed various derivatives of this scaffold and among them compound 23 from the series was found active with 1.8 μM on Aurora-B kinase luminescent assay [53]. Jeffe

• BI-7273 Long term blood pressure regulation is linked to ren

  2024-02-01

  

  Long term blood pressure regulation is linked to renal function through the mechanisms of pressure natriuresis (Evans et al., 2005), which has been shown to be modulated by the RAS (Hall et al., 1999). Key components of the RAS are expressed throughout the kidney, and are implicated in renal excreto

• Recently rather than predicting categorical variables as in

  2024-02-01

  

  Recently, rather than predicting categorical variables as in classification, several studies begin to estimate continuous clinical variables from MRS 1220 images. Therefore, instead of classify a subject into binary or multiple pre-determined categories or stages of the disease, regression focus on

• The study by Lo http

  2024-02-01

  

  The study by Lowry et al. (2001) pointed toward functionally uncharacterized DA- and 5-HT-accumulating neurons within the DMH as a potential target for rapid nongenomic effects of CORT. Similar DA- and 5-HT-accumulating systems are distributed throughout the central and peripheral nervous systems, s

• Derivatives of M that possess either

  2024-02-01

  

  Derivatives of (+)-M100907 that possess either an alkyne or an azide have been synthesized. The most active enantiomer was obtained by resolution of a relatively early intermediate in the synthesis. The ability of these Prostaglandin E2 to maintain 5-HTR antagonist properties as (+)-M100907 was dem

• growth hormone secretagogue br Materials and methods br

  2024-02-01

  

  Materials and methods Results Discussion More experiments were performed in order to explain the mechanism that is involved in growth hormone secretagogue death both PC3 and Hep G2 cells using compound 5. Results showed that this compound inhibits cell viability inducing apoptosis in a con

• In addition we performed Western blot analysis of different

  2024-02-01

  

  In addition, we performed Western-blot analysis of different areas of mouse brain with dynorphin against mAck1 (Ureña et al., 2005). The data obtained showed a high rate of expression in neocortex, hippocampus, cerebellum, and brainstem (Fig. 4). More moderate levels of expression were seen in hypot

• br AD and COX LOX

  2024-02-01

  

  AD and COX/5-LOX pharmacology Early studies on the role of cyclooxygenases in AD were inspired by epidemiological data suggesting that COX inhibitors such as nonsteroidal anti-inflammatory drugs (NSAIDs) could be beneficial in AD patients (Lucca et al., 1994, McGeer et al., 1990). This line of re

15827 records 193/1056 page Previous Next First page 上5页 191192193194195 下5页 Last page