• ANT located in the IMM

  2021-11-10

  

  ANT, located in the IMM, mediates the exchange of ATP/ADP between the mitochondrial matrix and the intermembrane space (IMS) (Brand et al., 2005; Palmieri and Pierri, 2010). Of the 4 known isoforms, ANT1 is the dominant isoform in the heart (Palmieri and Pierri, 2010). Under physiological conditions

• Failure of antioxidant defenses to

  2021-11-09

  

  Failure of antioxidant defenses to remove exogenous ROS produced by redox cycling chemicals either by being inhibited by those compounds or overwhelmed by an excess ROS, will disrupt the balance between antioxidant/prooxidant system within the organisms leading to oxidative damage (Livingstone, 2003

• The energy required to drive the

  2021-11-09

  

  The energy required to drive the functional process to actively maintain lens transparency is primarily derived from the metabolism of glucose. Since the lens is avascular and exists in an environment of low oxygen tension, glucose is primarily metabolized by experienced glycolysis (Kinoshita, 1965

• br Materials and methods br Results Unitary currents of Gard

  2021-11-09

  

  Materials and methods Results Unitary currents of Gardos igf 1 inhibitor were identified by their conductance value, inward rectification, voltage independence of open probability, kinetics and Ca2+-sensitivity, all features which have been described elsewhere [8], [13], [20], [23], [24], [25

• N-Nonyldeoxynojirimycin Macroautophagy hereafter referred to

  2021-11-09

  

  Macroautophagy (hereafter referred to as autophagy) depends on an intracellular lysosome-dependent degradation system that maintains cellular metabolism and homeostasis [11]. Genes involved in these processes are termed autophagy-related genes (ATGs), which regulate autophagosome formation and compl

• We compared the mixotrophic growth of

  2021-11-09

  

  We compared the mixotrophic growth of mutant DRHB1486 and the wild-type at different light intensities. The mutant grew at a similar rate as the wild-type at a low light intensity but much more slowly at a high light intensity (Fig. 3). Because the slr2094 mutant was unable to grow under photoautotr

• The presence of FBP in nuclei seems to accompany the

  2021-11-09

  

  The presence of FBP2 in nuclei seems to accompany the cells' potential to divide as it has been shown that during differentiation of the satellite cells (myogenic progenitor cells) the amount of nuclear FBP2 decreases and in differentiated myotubes, the localisation of FBP2 is restricted to cytoplas

• The molecular target of N BPs is farnesyl

  2021-11-09

  

  The molecular target of N-BPs is farnesyl diphosphate synthase (FPPS), a crucial enzyme at the branch point of cholesterol and isoprenoid synthesis in the mevalonate pathway [5]. Because they bind calcium ions, N-BPs accumulate quickly in the skeleton and are internalised by osteoclasts, leading to

• It is known that microglial function and morphology

  2021-11-09

  

  It is known that microglial function and morphology are closely related [20], but no studies have addressed whether neuroinflammation induced by alcohol might modify microglial CHIR-124 (i.e. morphology, neuroimmunochemical phenotype) through an eCB-dependent mechanism. Since this alcohol-induced m

• PKC does not however directly stimulate secretion by initiat

  2021-11-09

  

  PKC does not, however, directly stimulate secretion by initiating calcium influx into the cell [51]. Work from multiple groups measuring calcium currents has shown that PMA alone or coupled with glucose does not modulate intracellular calcium influx [34], [51], [52], [53]. Instead of contributing to

• A pyrimidine class of compounds is of

  2021-11-09

  

  A pyrimidine class of compounds is of enormous interest within anti-HIV drug discovery process for several decades, as pyrimidine based DABOs class [7], DAPYs class [8] are well known as NNRTIs as well as NRTIs. However, the overall role of a pyrimidine class of heterocycles in anti-HIV drug discove

• br Experimental br Acknowledgements This

  2021-11-08

  

  Experimental Acknowledgements This work was financially supported by Ministry of Knowledge and Economy (10032113) and Ministry of Education, Science and Technology (20100000297). Introduction To ensure accurate chromosome segregation, cohesion between sister chromatids must be maintained

• br Cellular directionality To obtain

  2021-11-08

  

  Cellular directionality To obtain a comprehensive understanding of cell migration, it is essential to understand how cues from the cell’s external environment are relayed to the guanabenz cytoskeleton, so the cell can migrate towards the cue; a process herein referred to as cellular directionalit

• br Clinical development of anti NASH drug therapies The curr

  2021-11-08

  

  Clinical development of anti-NASH drug therapies The current understanding of NASH pathogenesis has led to broad efforts to target several features of the disease, alone or in combination, even in the absence of liver-guided therapies. Therefore, drug development in NASH is a rapidly changing fie

• br Several reports have shown

  2021-11-08

  

  Several reports have shown an anti-proliferative effect of type I IFNs on CD4+ T ampicillin sodium activated in vitro either upon anti-CD3 antibody treatment [28,29] or upon cognate antigen stimulation [29]. However, the in vivo setting is a lot more complex, since the final outcome is the net ef

15876 records 543/1059 page Previous Next First page 上5页 541542543544545 下5页 Last page