• While TPO holds promise in thrombopoiesis and in promoting s

  2018-11-08

  

  While TPO holds promise in thrombopoiesis and in promoting stem cell proliferation and differentiation, phase II–III clinical trials of rhTPO and its shorter polyethylene glycol-conjugated form, PEG-rHuMGDF yielded mixed results. This was due to the fact that both were associated with autoantibodies

• Our hiPSC RPE cell sheets met general requirements in terms

  2018-11-08

  

  Our hiPSC-RPE cell sheets met general requirements, in terms of quality, quantity, consistency, and safety, for clinical-grade donor Merimepodib manufacturer intended for use in cell replacement therapy. These cell sheets expressed typical RPE markers, showed polarized secretion of PEDF and VEGF, a

• GABAA receptors GABAAR are heteropentameric ion channels wit

  2018-11-08

  

  GABAA receptors (GABAAR) are heteropentameric ion channels with prevalent expression on immature cells, including astrocyte-like SVZ cells, TACs and neuroblasts (Platel et al., 2010). Previous studies reveal that GABAAR activation decreases the proliferation of embryonic neocortical progenitors (Hay

• While the in vivo significance of

  2018-11-08

  

  While the in vivo significance of our in vitro findings was examined in xenograft and metastasis studies, we observed a dramatic suppression of tumor growth and metastasis of SW480 CRC order KPT-185 by EDA silencing, which is associated with increased apoptosis and reduced expression of a cell prol

• Because Foxd regulates stem cell properties in

  2018-11-08

  

  Because Foxd3 regulates stem cell properties in multiple lineages (Liu and Labosky, 2008; Hanna et al., 2002; Mundell et al., 2012; Mundell and Labosky, 2011; Teng et al., 2008; Tompers et al., 2005), Foxd3 target genes must regulate self-renewal, pluripotency, and/or survival of stem cells. Current

• Because Foxd regulates stem cell properties in

  2018-11-08

  

  Because Foxd3 regulates stem cell properties in multiple lineages (Liu and Labosky, 2008; Hanna et al., 2002; Mundell et al., 2012; Mundell and Labosky, 2011; Teng et al., 2008; Tompers et al., 2005), Foxd3 target genes must regulate self-renewal, pluripotency, and/or survival of stem cells. Current

• S P has an anti

  2018-11-08

  

  S1P has an anti-apoptotic and proliferative effect in ES cells and these S1P functions are contingent on the activation of MAPKs (Wong et al., 2007). Previously, it has been reported that S1P stimulates ERK, p38, or JNK phosphorylation, which is involved in the regulation of pluripotency of human ES

• br Conflict of interest br Acknowledgments

  2018-11-08

  

  Conflict of interest Acknowledgments Introduction In order to understand the molecular and physiological changes in neurons of the brains of individuals with disorders ranging from intellectual disability to autism, it is essential to study live neurons that accurately represent the conditi

• The alternative corneal epithelial stem

  2018-11-08

  

  The alternative corneal epithelial stem cell (CESC) hypothesis (Majo et al., 2008) accepts that LESCs exist but proposes that these are only used to repair wounds and that, during normal homeostasis, the corneal epithelium is maintained by stem cells, which are present throughout the corneal epithel

• br Resource table br Resource details Multiple endocrine neo

  2018-11-08

  

  Resource table Resource details Multiple endocrine neoplasia type 1 (MEN1) (also termed Wermer syndrome) is an autosomal dominant hereditary which is caused by mutations on the tumor suppressor gene MEN1. MEN1 is characterized by tumorigenesis mainly in endocrine organs including parathyroid g

• glycine transporter br Acknowledgments br Introduction Expre

  2018-11-08

  

  Acknowledgments Introduction Expression of a defined set of transcription factors (OCT4, SOX2, KLF4, and c-MYC) reprograms human somatic cells to a pluripotent state, generating induced pluripotent stem cells (iPSCs) (Park et al., 2008b; Takahashi et al., 2007; Yu et al., 2007). iPSCs are simi

• The concept of neoblast specialization at wounds is

  2018-11-08

  

  The concept of neoblast specialization at wounds is important in understanding planarian regeneration and opens many avenues for future inquiry. For example, how is the neoblast response tailored to the identity of missing tissues? Do specialized neoblasts amplify their population, or do specialized

• br Introduction The grafting of cultured keratinocytes

  2018-11-08

  

  Introduction The grafting of cultured keratinocytes to promote regeneration represents one of the oldest clinical examples of stem cell therapy (Green, 2008). The skin constitutes an essential barrier between the living tissues of the body and the external environment, and skin tissues have evolv

• In conclusion we expect that this

  2018-11-08

  

  In conclusion, we expect that this VP64dCas9-BFPVP64 platform, which is significantly more potent than previous versions, will encourage the adoption of CRISRP/Cas9-based TF technology to achieve multiplexed gene activation for reprogramming as well as nonreprogramming applications in basic science,

• Multiple mechanisms have been described that sensitize ESCs

  2018-11-08

  

  Multiple mechanisms have been described that sensitize ESCs to DNA damage-induced apoptosis. First, human ESCs possess unique ROCK-dependent mechanisms in singularized SC 144 that lead to a myosin-mediated form of cell blebbing, which rapidly triggers apoptosis upon cell detachment (Ohgushi et al.,

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