• br Outstanding Questions The therapeutics mentioned in this

  2018-11-01

  

  Outstanding Questions The therapeutics mentioned in this review are a small sample of some of the most promising clinical pharmacological approaches to tackling age-related diseases. Assessing the potential systemic anti-ageing effects of therapeutics currently used to treat specific age-related

• Remarkably we show here that

  2018-11-01

  

  Remarkably, we show here that in HLA-B*57+ ECs, the frequency of Env-specific B cells, correlated positively with the breadth of viruses neutralized. Previous studies analyzed potential correlations between antibody secreting cells and Ab responses (Bussmann et al., 2010; Doria-Rose et al., 2009). W

• br Materials and methods br Acknowledgments

  2018-11-01

  

  Materials and methods Acknowledgments We would like to thank all members of the Imhof and Heun group for critical discussions and feedback and the anonymous reviewer for valuable comments and suggestions to improve the manuscript. Work in the lab of A.I. was supported by grants from the German

• br Acknowledgments Francesco Palmas gratefully acknowledges

  2018-11-01

  

  Acknowledgments Francesco Palmas gratefully acknowledges Sardinia Regional Government (F.S.E. 2007-2013 UniCa) for the financial support of his PhD scholarship (P.O.R. Sardegna F.S.E. Operational Programme of the Autonomous Region of Sardinia, European Social Fund 2007–2013—Axis IV Human Resource

• br Brain signatures of increased reward sensitivity and redu

  2018-11-01

  

  Brain signatures of increased reward sensitivity and reduced cognitive control in youth with behavior problems As mentioned previously, developmental differences in VS recruitment by rewards during fMRI have been interpreted as reflecting underlying development of DA activity in the mesolimbic sy

• br Introduction The infancy period is arguably the most

  2018-11-01

  

  Introduction The infancy period is arguably the most important period for human zolmitriptan maturation, featuring both dramatic structural growth (Gilmore et al., 2007) and complex functional wiring (Tau and Peterson, 2010; Gao et al., 2014). To better delineate the functional brain development

• br Methods br Results br Discussion

  2018-11-01

  

  Methods Results Discussion The notion of trait hypoactivation in right aTPJ is intriguing given the temporoparietal junction\'s well-established roles in both social and attentional processes (for reviews see Carter and Huettel, 2013; Decety and Lamm, 2007). Due to the social nature of the

• br Conclusions A greater demand on

  2018-11-01

  

  Conclusions A greater demand on executive control functions might entail greater difficulties controlling retaliatory responses to negative treatment in the heat of the moment of everyday interactions with peers. In turn, retaliatory responses are likely to provoke excluders, which could elicit n

• At the age of years all three

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  At the age of 5 years, all three groups exhibited more negative responses to the deviant stimuli in the 335–535ms interval, and there was no group difference in the LDN mean amplitude. This suggests that the lexical tone perception abilities of late-talking children continue to develop with age, gro

• Unlike quantitative features of the cortical sheet such as t

  2018-11-01

  

  Unlike quantitative features of the cortical sheet, such as thickness, surface area (Giedd and Rapoport, 2010) and curvature/gyrification (Armstrong et al., 1995; Li et al., 2014; Raznahan et al., 2011; White et al., 2010) – which can take decades to attain the levels observed in adulthood–the quali

• Affective memory biases a key element of the cognitive

  2018-11-01

  

  Affective memory biases, a key element of the cognitive (Disner et al., 2011) and neuropsychological models of MDD (Roiser and Sahakian, 2013), are a common finding (Dalgleish and Werner-Seidler, 2014; Bradley and Mathews, 1988). Dalgleish and Werner-Seidler (2014) highlight the key components of th

• Studies examining attention bias towards happy faces are

  2018-11-01

  

  Studies examining attention bias towards happy faces are scarce. In the internalizing literature, increased attention towards happy faces is most commonly conceptualized as reflecting a bias towards rewards. Evidence suggesting that happy faces may be socially rewarding comes from fMRI studies in wh

• From a network dynamics perspective the amPFC is part of

  2018-11-01

  

  From a network dynamics perspective, the amPFC is part of the midline core components of the DMN and may underlie the evaluation of experiences with a high personal significance (Andrews-Hanna et al., 2010). In a detailed study of the structural and functional changes that occur in the DMN, Supekar

• Of KIT mutations seven occurred in

  2018-11-01

  

  Of 15 KIT mutations, seven occurred in ST 2825 11, five in exon 13, three in exon 17, and none in exon 18 (Table 2). The most common mutation was L576P (n = 6) and K642E (n = 6), followed by D820Y (n = 2), and finally Y559D (n = 1), L657F (n = 1), and G827R (n = 1). Although only three of 20 (15%)

• RO 4929097 manufacturer br Acknowledgments The authors are g

  2018-11-01

  

  Acknowledgments The authors are grateful to Rajesh S. Gokhale, director of CSIR-IGIB, for providing infrastructural facilities and financial assistance from CSIR (BSC0302) and Vivek T. Natarajan (CSIR-IGIB) for helpful discussions. R. Pathak would also like to acknowledge the University Grants Co

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