• glycine transporter br Acknowledgments br Introduction Expre

  2018-11-08

  

  Acknowledgments Introduction Expression of a defined set of transcription factors (OCT4, SOX2, KLF4, and c-MYC) reprograms human somatic cells to a pluripotent state, generating induced pluripotent stem cells (iPSCs) (Park et al., 2008b; Takahashi et al., 2007; Yu et al., 2007). iPSCs are simi

• The concept of neoblast specialization at wounds is

  2018-11-08

  

  The concept of neoblast specialization at wounds is important in understanding planarian regeneration and opens many avenues for future inquiry. For example, how is the neoblast response tailored to the identity of missing tissues? Do specialized neoblasts amplify their population, or do specialized

• br Introduction The grafting of cultured keratinocytes

  2018-11-08

  

  Introduction The grafting of cultured keratinocytes to promote regeneration represents one of the oldest clinical examples of stem cell therapy (Green, 2008). The skin constitutes an essential barrier between the living tissues of the body and the external environment, and skin tissues have evolv

• In conclusion we expect that this

  2018-11-08

  

  In conclusion, we expect that this VP64dCas9-BFPVP64 platform, which is significantly more potent than previous versions, will encourage the adoption of CRISRP/Cas9-based TF technology to achieve multiplexed gene activation for reprogramming as well as nonreprogramming applications in basic science,

• Multiple mechanisms have been described that sensitize ESCs

  2018-11-08

  

  Multiple mechanisms have been described that sensitize ESCs to DNA damage-induced apoptosis. First, human ESCs possess unique ROCK-dependent mechanisms in singularized SC 144 that lead to a myosin-mediated form of cell blebbing, which rapidly triggers apoptosis upon cell detachment (Ohgushi et al.,

• Although the disease specific phenotype identified in this

  2018-11-08

  

  Although the disease specific phenotype identified in this study will be invaluable for demonstrating the efficacy of gene based therapeutics, two major questions remain: 1) why do some patients with TRNT1 variants develop the severe syndromic disease SIFD while others (i.e. the three presented in t

• From previous studies we know

  2018-11-08

  

  From previous studies we know that cells above the bulge that are Sca-1 and CD34 negative also possess stem cell properties and that these stem cells are not label retaining cells, but relatively active in mg115 (Jensen et al., 2008). This suggests that LRCs primarily reflects a certain pattern of p

• Interestingly KLF and TFCP L are also involved in

  2018-11-08

  

  Interestingly, KLF2 and TFCP2L1 are also involved in LIF/STAT3-mediated ESC self-renewal. KLF2, which is functionally redundant with KLF4, a known target of LIF/STAT3 signaling, can maintain mESCs in an undifferentiated state in the presence of serum (Hall et al., 2009). TFCP2L1, a key target of LIF

• br Experimental Procedures br Acknowledgments We thank

  2018-11-08

  

  Experimental Procedures Acknowledgments We thank Drs. Robert Blelloch (UCSF) for the Dgcr8−/− ESCs, Jingyang Feng (Loyola Medical Center) for interpretation of histology results, Tim Townes (UAB) for comments on the manuscript, and the UAB Comprehensive Flow Cytometry Core (P30AR048311 and P30

• br Experimental Procedures br Author Contributions

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments This work was supported by grants from The Netherlands Organization for Health Research and Development (ZonMW-Grant nr. 11.600.1023), lipid metabolism pathway Netherlands Institute for Regenerative Medicine (NIRM, Grant No. FES09

• The second subtheme of an upset mind was

  2018-11-07

  

  The second subtheme of an upset mind was insomnia as a worrying experience. It describes the experience of different kinds of worrisome concerns in patients with insomnia. Concern about the progressive course of insomnia, development of a psychiatric disorder and the associated stigma, development o

• As already mentioned Rodrik provides an explanation

  2018-11-07

  

  As already mentioned, Rodrik (2006) provides an explanation called self-insurance protection against the capital outflows or changes in the exchange rate that may lead to a crisis. He also notes two types of costs involved in hoarding international reserves: (1) the spread between “the private secto

• Given the increasing intake of

  2018-11-07

  

  Given the increasing intake of high-fat and high-calorie diets in the post-industrialization era and the high prevalence of H. pylori infection at a global level, we therefore investigated the impact of H. pylori infection in combination with HFD on body insulin sensitivity and subsequent predisposi

• One thing that we learned in

  2018-11-07

  

  One thing that we learned in the presented ZIKV vaccine studies is that the yield of production of the ZIKV envelope E subunit protein was very low in the current format. This finding, also confirmed by a recently published ZIKV vaccine study (Larocca et al., 2016), is similar to what was previously

• For various cancer types HDAC acts as an

  2018-11-07

  

  For various cancer types, HDAC2 acts as an oncogene through the epigenetic regulation of genes and the corresponding signaling cascades in cancer development, and HDAC2 expression is gradually increases, from pre-neoplastic lesions, to low-grade dysplastic nodules, high-grade dysplastic nodules, and

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