• In our previous study we reported a genetic diagnosis

  2018-11-06

  

  In our previous study, we reported a genetic diagnosis of a GT patient with two different mutations in the two ITGA2B alleles. Both mutations activated a same recessive intron splicing site and cause a 99-base deletion in IIb mRNA (Li et al., 2011). In the current study, we successfully established

• Host pathogen interaction is a balancing

  2018-11-06

  

  Host-pathogen interaction is a balancing act as viruses evolved to have strategies to evade the host defense system. HCV NS3, core and NS5A proteins are involved in immune evasion by modulating specific and innate immune pathways (Basu et al., 2001; Horner and Gale, 2013). NS3 protease can effective

• Our coculture experiments demonstrated that all

  2018-11-06

  

  Our coculture experiments demonstrated that all three MSCs showed a similar low in vitro proliferation; for most patients coculture of all three MSCs with primary human AML DMXAA did not alter MSC proliferation but a minor increase in the proliferation was seen for a minority of patients. No or onl

• The last aspect we want to address in this review

  2018-11-06

  

  The last aspect we want to address in this review is the importance of suitable cell culture conditions for targeting and single cell cloning of human PSCs. This is probably the most challenging aspect since there are significant variances between different human PSC clones concerning proliferation,

• Despite these achievements in iNSC technology little

  2018-11-06

  

  Despite these achievements in iNSC technology, little is known on how cellular identities of iNSCs differ from those of NSCs in comparison to pluripotent stem cell-derived NPCs. For instance, it is currently unknown to what extent neural, metabolic and stress response pathways differ between these n

• br Materials and methods br Acknowledgments

  2018-11-06

  

  Materials and methods Acknowledgments We would like to thank Dr. Keisuke Okita and Prof. Shinya Yamanaka for providing the plasmids for reprogramming. We thank Bente Smith Thorup for excellent technical assistance in the cell culture. We thank Mehri Mirrajei for cytogenetic technical assistanc

• The SWI SNF complex consists of

  2018-11-06

  

  The SWI/SNF complex consists of 15 core subunits whose unique composition is critical for its distinct functions in different types of cells (Kadoch et al., 2013; Wu et al., 2009). In our study, we demonstrated that both BAF170 and BAF155 existed in the human BRG1-SWI/SNF complex and were enriched

• The DNA damage repair system involves a complex

  2018-11-05

  

  The DNA damage repair system involves a complex network in which miRNAs play important roles (Chen and Rajewsky, 2007; Song et al., 2011; Wan et al., 2011). For example, miR-24 and miR-138 can downregulate H2AX, leading to high sensitivity to radiation and weak repair capacity (Lal et al., 2009). mi

• One therapeutic approach for SCI is

  2018-11-05

  

  One therapeutic approach for SCI is cell transplantation. For this Torin1 approach, cell survival is also a critical variable for preclinical models. The advantages of constitutively immunodeficient mice versus immunosuppression in immunocompetent mice in achieving maximal donor cell engraftment for

• br Experimental Procedures br Author Contributions br Acknow

  2018-11-05

  

  Experimental Procedures Author Contributions Acknowledgments We thank Dr. Yao Zhi for performing the calcium studies. This study was supported by MRC CoEN grants MR/J009660/1 and MR/L501499/1, and MRC Experimental Medicine grant MR/M006646/1, the Kattan Trust, and Javon Trust. A.H.V.S. is a

• There was an attempt to explain the physiological meaning

  2018-11-05

  

  There was an attempt to explain the physiological meaning of the balance between the oligomeric and the monomeric forms of the sigma-1 receptor by the hypothesis that oligomerization of the sigma-1 receptor regulates its ligand-mediated functions [57]. Presumably, the sigma-1 receptor ligands can in

• br Summary A new niobium diffusion mechanism at

  2018-11-05

  

  Summary A new niobium pacap mechanism at the copper–niobium interfacial boundary characterized by the displacement of atoms along the mismatch dislocations has been established. Diffusion processes in niobium are activated by the introduction of a number of copper atoms in the rows of niobium ato

• To our knowledge this is the first study to

  2018-11-05

  

  To our knowledge, this is the first study to empirically test the claim that flexicurity policies have the capacity to attenuate the adverse health consequences of temporary employment across a large sample of advanced capitalist countries. Prior studies have challenged the notion that flexicurity c

• In many ways religiosity is easier to

  2018-11-05

  

  In many ways, religiosity is easier to quantify than spirituality. Because of the abstraction involved with the concept, survey research often includes indirect indicators of spirituality, such as the item referred to in Table 1. This type of measure demonstrates the broadness of spirituality. In so

• br Acknowledgments br Introduction Despite a lower socio eco

  2018-11-05

  

  Acknowledgments Introduction Despite a lower socio-economic status, children of first-generation immigrants of Hispanic origin have better birth outcomes than children of US born white women (Acevedo-Garcia, Soobader, & Berkman, 2007). However, previous studies have shown that birth outcomes d

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