• As an initial application of our RNA seq datasets

  2018-10-24

  

  As an initial application of our RNA-seq datasets for discovery of regulatory mechanisms in huSCs, we compared transcriptomes of quiescent huSCs to those of activated huSCs to identify loci that were differentially expressed. In quiescent huSCs, we identified 998 highly expressed genes, including 13

• We and others have shown previously that the evolutionarily

  2018-10-24

  

  We and others have shown previously that the evolutionarily conserved Notch signaling pathway plays an important role in early embryonic pituitary development (Kita et al., 2007; Raetzman et al., 2004, 2007; Zhu et al., 2006). Delta/Notch signaling, mediated by the critical transcription factor RBP-

• Results br Discussion Expansion of the NP population

  2018-10-24

  

  Results Discussion Expansion of the NP population is thought to have contributed to the dramatic increase in the surface area of the neocortex (or neocorticalization) observed in higher mammals (Kriegstein et al., 2006; Rakic, 2009; Sun and Hevner, 2014). Thus, maintenance of the NP pool size an

• To gain further insight into progenitor cells derived from h

  2018-10-24

  

  To gain further insight into progenitor carboxypeptidase b derived from human skeletal muscle, we performed comprehensive cell-surface protein profiling of two progenitor populations, CD56+ myogenic progenitors and PDGFRα+ mesenchymal progenitors. This comprehensive analysis identified previously un

• Actively dividing B cells aNSCs in our study were shown

  2018-10-24

  

  Actively dividing B1 purchase BLZ945 (aNSCs in our study) were shown to go through three rounds of divisions before differentiating into C cells (referred as TACs in our study) (Ponti et al., 2013). However, the mechanisms regulating their behavior both in vitro and in vivo are still not known. Our

• In in vivo animal models

  2018-10-24

  

  In in vivo animal models, we observed no rejection signs in the iPS-RPE allografts of MHC-matched monkeys (DrpZ1 and DrpZ17); for example, fundus photographs revealed no exudation, FA showed no vascular leakage of fluorescein, and OCT indicated there was no retinal edema around the transplanted RPE

• br Experimental Procedures br Author Contributions br

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments This work is supported by national Portuguese funding through FCT, Fundação para a Ciência e a Tecnologia, project UID/BIM/04773/2013 CBMR, projects PEst-OE/EQB/LA0023/2013 and PTDC/SAU-ENB/111702/2009 to J.B., U01HL100408, NIH/N

• pteryxin cost br Experimental Procedures br Author Contribut

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We wish to thank the cytometer unit of CABIMER for technical support, Diana Aguilar for critical reading of the manuscript, and Veronica Raker for style corrections. This work was funded by an R + D + I grant from the Spanish Mini

• Although previous studies have demonstrated the ability of r

  2018-10-24

  

  Although previous studies have demonstrated the ability of research-grade HuCNS-SC lines to differentiate in both immune-suppressed and immune-deficient models (Cummings et al., 2005; Sontag et al., 2014; Ager et al., 2015), we observed no terminal differentiation in the current study. In our prior

• Dedifferentiation has been considered as

  2018-10-24

  

  Dedifferentiation has been considered as one of the mechanisms rerouting cell fate by reverting differentiated cells to an earlier, more primitive phenotype. Interestingly, previous studies from both our group and others have demonstrated that dedifferentiation is a prerequisite for bone marrow stro

• The electrical properties of cells were

  2018-10-24

  

  The electrical properties of pi3k activation were recently analyzed by EIS during the differentiation of stem cells (Angstmann et al., 2011; Bagnaninchi and Drummond, 2011; Venkatanarayanan et al., 2013). These pioneering works have demonstrated a possibility of using changes in impedance as a bioma

• We speculated that MEKi might decrease DNA methylation

  2018-10-24

  

  We speculated that MEKi might decrease DNA methylation levels through the downregulation of the DNMT3 family. MEKi significantly diminished global DNA methylation levels and, surprisingly, was sufficient to induce high 5hmC levels. Because the TET family of dioxygenases that catalyze the conversion

• The presented hMOs have a great

  2018-10-24

  

  The presented hMOs have a great potential to be used for in vitro modeling of diseases that strongly affect the human midbrain, particularly PD (Michel et al., 2016). Patient-specific hMOs might reveal specific phenotypes that are not abundant in 2D cultures and therefore may be used for mechanistic

• br The technique of processing the time

  2018-10-24

  

  The technique of processing the time series of solar flare HXR The technique of processing the experimental data obtained using the BATSE spectrometer for simple single-pulse events is described in Ref. [3]. In essence, the technique entails constructing a mutual correlation function (MCF) for al

• br The technique of processing the time

  2018-10-24

  

  The technique of processing the time series of solar flare HXR The technique of processing the experimental data obtained using the BATSE spectrometer for simple single-pulse events is described in Ref. [3]. In essence, the technique entails constructing a mutual correlation function (MCF) for al

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