Archives
- 2018-07
- 2018-10
- 2018-11
- 2019-04
- 2019-05
- 2019-06
- 2019-07
- 2019-08
- 2019-09
- 2019-10
- 2019-11
- 2019-12
- 2020-01
- 2020-02
- 2020-03
- 2020-04
- 2020-05
- 2020-06
- 2020-07
- 2020-08
- 2020-09
- 2020-10
- 2020-11
- 2020-12
- 2021-01
- 2021-02
- 2021-03
- 2021-04
- 2021-05
- 2021-06
- 2021-07
- 2021-08
- 2021-09
- 2021-10
- 2021-11
- 2021-12
- 2022-01
- 2022-02
- 2022-03
- 2022-04
- 2022-05
- 2022-06
- 2022-07
- 2022-08
- 2022-09
- 2022-10
- 2022-11
- 2022-12
- 2023-01
- 2023-02
- 2023-03
- 2023-04
- 2023-05
- 2023-06
- 2023-07
- 2023-08
- 2023-09
- 2023-10
- 2023-11
- 2023-12
- 2024-01
- 2024-02
- 2024-03
- 2024-04
- 2024-05
- 2024-06
- 2024-07
- 2024-08
- 2024-09
- 2024-10
- 2024-11
- 2024-12
- 2025-01
- 2025-02
- 2025-03
- 2025-09
- 2025-10
-
Filipin III: Precision Cholesterol Mapping for Advanced M...
2025-10-02
Explore the unique specificity of Filipin III, a polyene macrolide antibiotic, as a fluorescent probe for cholesterol detection in membranes. This article delivers an advanced, mechanistic perspective on Filipin III's role in visualizing cholesterol-rich microdomains and decoding cellular lipid homeostasis.
-
Acetylcysteine (NAC): Optimizing Oxidative Stress and Tum...
2025-10-01
Acetylcysteine (N-acetylcysteine, NAC) distinguishes itself as both an antioxidant precursor for glutathione biosynthesis and a mucolytic agent for respiratory research, powering advanced experimental models. This guide reveals how to leverage NAC for robust oxidative stress pathway modulation, precision in 3D cancer co-cultures, and effective troubleshooting for reproducible results.
-
TNF-alpha Recombinant Murine Protein: Illuminating Non-Ca...
2025-09-30
Explore how TNF-alpha recombinant murine protein drives breakthroughs in apoptosis and immune modulation research. This article uniquely dissects emerging non-canonical cell death mechanisms, integrating the latest findings and technical advances for cutting-edge cytokine studies.
-
Sildenafil Citrate: Unraveling Proteoform-Specific Signal...
2025-09-29
Explore how Sildenafil Citrate, a selective cGMP-specific phosphodiesterase type 5 inhibitor, enables cutting-edge analysis of proteoform-specific signaling in vascular and pulmonary research. This article uniquely focuses on advanced experimental strategies and the impact of proteoform diversity on drug specificity and efficacy.
-
2025-09-28
Explore how 2'3'-cGAMP (sodium salt) drives breakthroughs in STING-mediated innate immune response and immunotherapy research. This in-depth analysis reveals unique mechanistic insights and translational opportunities beyond existing literature.
-
Cy5-UTP: Pushing the Frontiers of Fluorescent RNA Labeling
2025-09-27
Discover how Cy5-UTP (Cyanine 5-uridine triphosphate) redefines fluorescently labeled UTP for RNA labeling, enabling high-resolution studies of RNA-protein dynamics and phase separation. This article goes beyond probe synthesis, offering a deeper perspective on mechanistic insights and advanced molecular biology applications.
-
HyperScribe™ T7 High Yield Cy5 RNA Labeling Kit: Illumina...
2025-09-26
Explore how the HyperScribe™ T7 High Yield Cy5 RNA Labeling Kit enables next-generation fluorescent RNA probe synthesis for dissecting complex RNA–protein interactions, including phase separation phenomena. Uncover unique insights into fluorescent nucleotide incorporation, advanced gene expression analysis, and applications in virology.
-
Nebivolol Hydrochloride: Precision β1 Blockade in Cardiov...
2025-09-25
Explore the distinctive role of Nebivolol hydrochloride as a highly selective β1-adrenoceptor antagonist in cardiovascular pharmacology and pathway-selective research. This in-depth article uncovers its advanced applications, specificity, and new insights into adrenergic and non-adrenergic signaling, setting it apart from prior reviews.
-
Rotenone as a Precision Tool: Advancing Mitochondrial Com...
2025-09-24
Explore how Rotenone, a mitochondrial Complex I inhibitor, enables advanced interrogation of mitochondrial proteostasis and metabolic regulation. This article uniquely integrates recent findings on post-translational enzyme control, expanding its relevance for neurodegenerative disease and cell signaling research.
-
BGJ398 (NVP-BGJ398): Illuminating FGFR2 Signaling in Canc...
2025-09-23
BGJ398 (NVP-BGJ398) is a selective FGFR1/2/3 inhibitor widely utilized in oncology research for dissecting FGFR-driven malignancies and developmental signaling pathways. This article explores its mechanistic role in cancer models and highlights its utility in studying FGFR2-mediated processes, drawing connections to advanced developmental biology.
-
Maximizing mRNA Therapeutics with HyperScribe™ Poly (A) T...
2025-09-19
Explore how the HyperScribe™ Poly (A) Tailing Kit advances polyadenylation of RNA transcripts for enhanced mRNA stability and translation efficiency in research applications. This article provides a rigorous review of the kit’s mechanism, its relevance to in vitro mRNA therapeutics, and emerging insights from recent scientific literature.
-
Phenacetin in hiPSC-Derived Intestinal Organoids: New Fro...
2025-09-18
Explore the application of Phenacetin (N-(4-ethoxyphenyl)acetamide) in advanced pharmacokinetic studies using human pluripotent stem cell-derived intestinal organoids. This article highlights methodological advances and unique research opportunities with this non-opioid analgesic.
-
Accumulating evidence suggest that patients with
2025-03-03
Accumulating evidence suggest that patients with advanced -positive NSCLC are at increased risk of VTE or coagulation disorders during the course of their disease, indicating that cancer genotype might play a role in the occurrence of cancer-related thromboembolism . Here we report the case of a pat
-
br Conclusion br Introduction Lung cancer
2025-03-03
Conclusion Introduction Lung cancer is the principal cause of death by cancer and the third most common cancer worldwide (Sorber et al., 2016). Lung cancer has two main types: small cell carcinomas (approximately 20%) and non-small cell lung cancers (NSCLC) (about 80%) (Fan et al., 2016). NSC
-
br Disclosures br Author contributions br
2025-03-03
Disclosures Author contributions Grants This work was supported by National Institutes of Health/National Heart, Lung, and Blood Institute MERIT Award R37 HL040696 to J.A.F. Acknowledgments Introduction The AGC kinases, named after the protein A, G and C kinases, are an evolutionaril